Imaging


Ongoing Projects

Primary 2: Prospective multi-centre randomised trial of the additive diagnostic value of PSMA PET in men with negative/equivocal MRI in the diagnosis of significant prostate cancer (PSMA-PET imaging)
CLARIFY: Positron Emission Tomography using 64Cu-SAR-bisPSMA in participants with high-risk prostate cancer prior to radical prostatectomy: A prospective, single-arm, multi-center, blinded-review, Phase 3 diagnostic performance study (Imaging)

Our Publications on Imaging

Algohary, A., Shiradkar, R., Pahwa, S., Purysko, A., Verma, S., Moses, D., … Madabhushi, A. (2020). Combination of Peri-Tumoral and Intra-Tumoral Radiomic Features on Bi-Parametric MRI Accurately Stratifies Prostate Cancer Risk: A Multi-Site Study. Cancers , 12 (8). https://doi.org/10.3390/cancers12082200
Algohary, A., Viswanath, S., Shiradkar, R., Ghose, S., Pahwa, S., Moses, D., … Madabhushi, A. (2018). Radiomic features on MRI enable risk categorization of prostate cancer patients on active surveillance: Preliminary findings. Journal of Magnetic Resonance Imaging : JMRI . https://doi.org/10.1002/jmri.25983
Emmett, L., Buteau, J., Papa, N., Moon, D., Thompson, J., Roberts, M. J., … Stricker, P. (2021). The Additive Diagnostic Value of Prostate-specific Membrane Antigen Positron Emission Tomography Computed Tomography to Multiparametric Magnetic Resonance Imaging Triage in the Diagnosis of Prostate Cancer (PRIMARY): A Prospective Multicentre Study. European Urology , 80 (6), 682–689. https://doi.org/10.1016/j.eururo.2021.08.002
Emmett, L., Tang, R., Nandurkar, R., Hruby, G., Roach, P., Watts, J. A., … Science, M. (2019). 3 year freedom from progression following 68 GaPSMA PET CT triaged management in men with biochemical recurrence post radical prostatectomy . Results of a prospective multi‐center. Journal of Nuclear Medicine , epub ahead . https://doi.org/10.2967/jnumed.119.235028
Emmett, L., Van Leeuwen, P., Nandurkar, R., Scheltema, M. J., Cusick, T., Hruby, G., … Stricker, P. (2017). Treatment outcomes from 68 GaPSMA PET CT informed salvage radiation treatment in men with rising PSA following radical prostatectomy: Prognostic value of a negative PSMA PET. Journal of Nuclear Medicine , jnumed.117.196683. https://doi.org/10.2967/jnumed.117.196683
Huits, T. H., Luiting, H. B., van der Poel, H. G., Nandurkar, R., Donswijk, M., Schaake, E., … van Leeuwen, P. J. (2020). Distribution of prostate cancer recurrences on gallium-68 prostate-specific membrane antigen ((68) Ga-PSMA) positron-emission/computed tomography after radical prostatectomy with pathological node-positive extended lymph node dissection. BJU International , 125 (6), 876–883. https://doi.org/10.1111/bju.15052
Morigi, J. J., Stricker, P. D., van Leeuwen, P. J., Tang, R., Ho, B., Nguyen, Q., … Emmett, L. (2015). Prospective Comparison of 18F-Fluoromethylcholine Versus 68Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Authored Therapy. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine , 56 (8), 1185–1190. https://doi.org/10.2967/jnumed.115.160382
Nandurkar, R., van Leeuwen, P., Stricker, P., Woo, H., Kooner, R., Yuen, C., … Emmett, L. (2019). (68)Ga-HBEDD PSMA-11 PET/CT staging prior to radical prostatectomy in prostate cancer patients: Diagnostic and predictive value for the biochemical response to surgery. The British Journal of Radiology , 92 (1095), 20180667. https://doi.org/10.1259/bjr.20180667
Penzias, G., Singanamalli, A., Elliott, R., Gollamudi, J., Shih, N., Feldman, M., … Madabhushi, A. (2018). Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings. PloS One , 13 (8), e0200730. https://doi.org/10.1371/journal.pone.0200730
Roach, P. J., Francis, R., Emmett, L., Hsiao, E., Kneebone, A., Hruby, G., … Scott, A. M. (2018). The Impact of (68)Ga-PSMA PET/CT on Management Intent in Prostate Cancer: Results of an Australian Prospective Multicenter Study. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine , 59 (1), 82–88. https://doi.org/10.2967/jnumed.117.197160
Rusu, M., Purysko, A. S., Verma, S., Kiechle, J., Gollamudi, J., Ghose, S., … Madabhushi, A. (2017). Computational imaging reveals shape differences between normal and malignant prostates on MRI. Scientific Reports , 7 , 41261. https://doi.org/10.1038/srep41261
Thompson, J. E., Van Leeuwen, P. J., Moses, D., Shnier, R., Brenner, P., Delprado, W., … Stricker, P. D. (2016). The diagnostic performance of multiparametric magnetic resonance imaging to detect significant prostate cancer. Journal of Urology , 195 (5), 1428–1435. https://doi.org/10.1016/j.juro.2015.10.140
Thompson, James E., Moses, D., Shnier, R., Brenner, P., Delprado, W., Ponsky, L., … Stricker, P. D. (2014). Multiparametric magnetic resonance imaging guided diagnostic biopsy detects significant prostate cancer and could reduce unnecessary biopsies and over detection: A prospective study. Journal of Urology , 192 (1), 67–74. https://doi.org/10.1016/j.juro.2014.01.014
Thompson, James E, & Stricker, P. D. (2017). Diagnostic accuracy of multi-parametric MRI and transrectal ultrasound-guided biopsy in prostate cancer. Lancet (London, England) , 389 (10071), 767–768. https://doi.org/10.1016/S0140-6736(17)30121-6
Tran, M., Thompson, J., Böhm, M., Pulbrook, M., Moses, D., Shnier, R., … Stricker, P. D. (2016). Combination of multiparametric MRI and transperineal template-guided mapping biopsy of the prostate to identify candidates for hemi-ablative focal therapy. BJU International , 117 (1), 48–54. https://doi.org/10.1111/bju.13090
van Leeuwen, P. J., Donswijk, M., Nandurkar, R., Stricker, P., Ho, B., Heijmink, S., … Emmett, L. (2019). Gallium-68-prostate-specific membrane antigen ((68) Ga-PSMA) positron emission tomography (PET)/computed tomography (CT) predicts complete biochemical response from radical prostatectomy and lymph node dissection in intermediate- and high-risk prostate c. BJU International , 124 (1), 62–68. https://doi.org/10.1111/bju.14506
van Leeuwen, P. J., Emmett, L., Ho, B., Delprado, W., Ting, F., Nguyen, Q., & Stricker, P. D. (2017). Prospective evaluation of 68Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer. BJU International , 119 (2), 209–215. https://doi.org/10.1111/bju.13540
van Leeuwen, P. J., Hayen, A., Thompson, J. E., Moses, D., Shnier, R., Böhm, M., … Stricker, P. D. (2017). A multiparametric magnetic resonance imaging-based risk model to determine the risk of significant prostate cancer prior to biopsy. BJU International , 120 (6), 774–781. https://doi.org/10.1111/bju.13814
van Leeuwen, P. J., Stricker, P., Hruby, G., Kneebone, A., Ting, F., Thompson, B., … Emmett, L. (2016). (68) Ga-PSMA has a high detection rate of prostate cancer recurrence outside the prostatic fossa in patients being considered for salvage radiation treatment. BJU International , 117 (5), 732–739. https://doi.org/10.1111/bju.13397
Emmett, L., Papa, N., Buteau, J., Ho, B., Liu, V., Roberts, M., Thompson, J., Moon, D., Sheehan-Dare, G., Alghazo, O., Agrawal, S., Murphy, D., Stricker, P., Hope, T. A., & Hofman, M. S. (2022). The PRIMARY Score: Using Intraprostatic 68Ga-PSMA PET/CT Patterns to Optimize Prostate Cancer Diagnosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 63(11), 1644–1650. https://doi.org/10.2967/jnumed.121.263448
Roberts, M. J., Chatfield, M. D., Hruby, G., Nandurkar, R., Roach, P., Watts, J. A., Cusick, T., Kneebone, A., Eade, T., Ho, B., Nguyen, A., Tang, C., McCarthy, M., Francis, R., Stricker, P., & Emmett, L. (2022). Event-free survival after radical prostatectomy according to prostate-specific membrane antigen-positron emission tomography and European Association of Urology biochemical recurrence risk groups. BJU international, 130 Suppl 3(Suppl 3), 32–39. https://doi.org/10.1111/bju.15762
Ptasznik, G., Papa, N., Kelly, B. D., Thompson, J., Stricker, P., Roberts, M. J., Hofman, M. S., Buteau, J., Murphy, D. G., Emmett, L., & Moon, D. (2022). High prostate-specific membrane antigen (PSMA) positron emission tomography (PET) maximum standardized uptake value in men with PI-RADS score 4 or 5 confers a high probability of significant prostate cancer. BJU international, 130 Suppl 3(Suppl 3), 5–7. https://doi.org/10.1111/bju.15736
Doan, P., Counter, W., Papa, N., Sheehan-Dare, G., Ho, B., Lee, J., Liu, V., Thompson, J. E., Agrawal, S., Roberts, M. J., Buteau, J., Hofman, M. S., Moon, D., Lawrentschuk, N., Murphy, D., Stricker, P. D., & Emmett, L. (2023). Synchronous vs independent reading of prostate-specific membrane antigen positron emission tomography (PSMA-PET) and magnetic resonance imaging (MRI) to improve diagnosis of prostate cancer. BJU international, 131(5), 588–595. https://doi.org/10.1111/bju.15929
Vis, A. N., Meijer, D., Roberts, M. J., Siriwardana, A. R., Morton, A., Yaxley, J. W., Samaratunga, H., Emmett, L., van de Ven, P. M., Heymans, M. W., Nieuwenhuijzen, J. A., van der Poel, H. G., Donswijk, M. L., Boellaard, T. N., Schoots, I. G., Stricker, P., Haynes, A. M., Oprea-Lager, D. E., Coughlin, G. D., & van Leeuwen, P. J. (2023). Development and External Validation of a Novel Nomogram to Predict the Probability of Pelvic Lymph-node Metastases in Prostate Cancer Patients Using Magnetic Resonance Imaging and Molecular Imaging with Prostate-specific Membrane Antigen Positron Emission Tomography. European urology oncology, 6(6), 553–563. https://doi.org/10.1016/j.euo.2023.03.010
Kelly, B. D., Ptasznik, G., Roberts, M. J., Doan, P., Stricker, P., Thompson, J., Buteau, J., Chen, K., Alghazo, O., O'Brien, J. S., Hofman, M. S., Frydenberg, M., Lawrentschuk, N., Lundon, D., Murphy, D. G., Emmett, L., & Moon, D. (2023). A Novel Risk Calculator Incorporating Clinical Parameters, Multiparametric Magnetic Resonance Imaging, and Prostate-Specific Membrane Antigen Positron Emission Tomography for Prostate Cancer Risk Stratification Before Transperineal Prostate Biopsy. European urology open science, 53, 90–97. https://doi.org/10.1016/j.euros.2023.05.002
Samaneh Azargoshasb, Hilda A. de Barros, Daphne D.D. Rietbergen, Paolo Dell’Oglio, Pim J. van Leeuwen, Christian Wagner, Phillip Stricker, Sergi Vidal-Sicart, Alberto Briganti, Tobias Maurer, Henk G. van der Poel, Matthias N. van Oosterom, Fijs W. B. van Leeuwen. Artificial Intelligence-Supported Video Analysis as a Means to Assess the Impact of DROP-IN Image Guidance on Robotic Surgeons: Radioguided Sentinel Lymph Node versus PSMA-Targeted Prostate Cancer Surgery. Advanced Intelligent Systems journal. 2023. https://doi.org/10.1002/aisy.202300192
Li, L., Shiradkar, R., Tirumani, S. H., Bittencourt, L. K., Fu, P., Mahran, A., Buzzy, C., Stricker, P. D., Rastinehad, A. R., Magi-Galluzzi, C., Ponsky, L., Klein, E., Purysko, A. S., & Madabhushi, A. (2023). Novel radiomic analysis on bi-parametric MRI for characterizing differences between MR non-visible and visible clinically significant prostate cancer. European journal of radiology open, 10, 100496. https://doi.org/10.1016/j.ejro.2023.100496