Active Surveillance


Ongoing Projects

PIAS: Prospective cross-sectional study of the diagnostic utility of Ga-68 PSMA PET CT in addition to mpMRI for men undergoing saturation transperineal biopsy during Active Surveillance for low-risk or favourable intermediate-risk prostate cancer
Worldwide collaboration of Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) consortium to share data to evaluate Active Surveillance

Our Publications on Active Surveillance

Amin, A., Scheltema, M. J., Shnier, R., Blazevski, A., Moses, D., Cusick, T., … Thompson, J. (2020). The Magnetic Resonance Imaging in Active Surveillance (MRIAS) Trial: Use of Baseline Multiparametric Magnetic Resonance Imaging and Saturation Biopsy to Reduce the Frequency of Surveillance Prostate Biopsies. The Journal of Urology, 203 (5), 910–917. https://doi.org/10.1097/JU.0000000000000693
Bayliss, D. R., Duff, J., Stricker, P., & Walker, K. (2017). Decision-Making in Prostate Cancer – Choosing Active Surveillance Over Other Treatment Options: A Literature Review. Urologic Nursing, 37 (1), 15–22.
Grogan, J., Gupta, R., Mahon, K. L., Stricker, P. D., Haynes, A.-M., Delprado, W., … Kench, J. G. (2017). Predictive value of the 2014 International Society of Urological Pathology grading system for prostate cancer in patients undergoing radical prostatectomy with long-term follow-up. BJU International, 120 (5), 651–658. https://doi.org/10.1111/bju.13857
Hossack, T., Patel, M. I., Huo, A., Brenner, P., Yuen, C., Spernat, D., … Stricker, P. (2012). Location and pathological characteristics of cancers in radical prostatectomy specimens identified by transperineal biopsy compared to transrectal biopsy. The Journal of Urology , 188 (3), 781–785. https://doi.org/10.1016/j.juro.2012.05.006
Huo, A. S. Y., Hossack, T., Symons, J. L. P., PeBenito, R., Delprado, W. J., Brenner, P., & Stricker, P. D. (2012). Accuracy of primary systematic template guided transperineal biopsy of the prostate for locating prostate cancer: a comparison with radical prostatectomy specimens. The Journal of Urology , 187 (6), 2044–2049. https://doi.org/10.1016/j.juro.2012.01.066
King, M. T., Viney, R., Smith, D. P., Hossain, I., Street, D., Savage, E., … Armstrong, B. K. (2012). Survival gains needed to offset persistent adverse treatment effects in localised prostate cancer. British Journal of Cancer , 106 (4), 638–645. https://doi.org/10.1038/bjc.2011.552
Olivier, J., Li, W., Nieboer, D., Helleman, J., Roobol, M., Gnanapragasam, V., … Villers, A. (2022). Prostate Cancer Patients Under Active Surveillance with a Suspicious Magnetic Resonance Imaging Finding Are at Increased Risk of Needing Treatment: Results of the Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consort. European Urology Open Science, 35 , 59–67. https://doi.org/10.1016/j.euros.2021.11.006
Quinn, D. I., Henshall, S. M., Brenner, P. C., Kooner, R., Golovsky, D., O’Neill, G. F., … Stricker, P. D. (2003). Prognostic significance of preoperative factors in localized prostate carcinoma treated with radical prostatectomy: importance of percentage of biopsies that contain tumor and the presence of biopsy perineural invasion. Cancer , 97 (8), 1884–1893. https://doi.org/10.1002/cncr.11263
Rasiah, K. K., Stricker, P. D., Haynes, A.-M., Delprado, W., Turner, J. J., Golovsky, D., … Henshall, S. M. (2003). Prognostic significance of Gleason pattern in patients with Gleason score 7 prostate carcinoma. Cancer, 98 (12), 2560–2565. https://doi.org/10.1002/cncr.11850
Symons, J. L., Huo, A., Yuen, C. L., Haynes, A.-M., Matthews, J., Sutherland, R. L., … Stricker, P. D. (2013). Outcomes of transperineal template-guided prostate biopsy in 409 patients. BJU International, 112 (5), 585–593. https://doi.org/10.1111/j.1464-410X.2012.11657.x
Thompson, J. E., Hayen, A., Landau, A., Haynes, A.-M., Kalapara, A., Ischia, J., … Stricker, P. D. (2015). Medium-term oncological outcomes for extended vs saturation biopsy and transrectal vs transperineal biopsy in active surveillance for prostate cancer. BJU International, 115 (6), 884–891. https://doi.org/10.1111/bju.12858
Ting, F., van Leeuwen, P. J., Delprado, W., Haynes, A.-M., Brenner, P., & Stricker, P. D. (2015). Tumor volume in insignificant prostate cancer: Increasing the threshold is a safe approach to reduce over-treatment. The Prostate , 75 (15), 1768–1773. https://doi.org/10.1002/pros.23062
van Leeuwen, P. J., Siriwardana, A., Roobol, M., Ting, F., Nieboer, D., Thompson, J., … Stricker, P. (2016). Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies. Prostate Cancer , 2016 , 7105678. https://doi.org/10.1155/2016/7105678
Beckmann, K., Santaolalla, A., Helleman, J., Carroll, P., Ha Chung, B., Shiong Lee, L., Perry, A., Rubio-Briones, J., Sugimoto, M., Trock, B., Valdagni, R., Dasgupta, P., Van Hemelrijck, M., Elhage, O., & Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium (2021). Comparison of Characteristics, Follow-up and Outcomes of Active Surveillance for Prostate Cancer According to Ethnicity in the GAP3 Global Consortium Database. European urology open science, 34 , 47–54. https://doi.org/10.1016/j.euros.2021.09.012
Beckmann, K. R., Bangma, C. H., Helleman, J., Bjartell, A., Carroll, P. R., Morgan, T., Nieboer, D., Santaolalla, A., Trock, B. J., Valdagni, R., Roobol, M. J., & Global Action Plan Active Surveillance Prostate Cancer [G.A.P.3] Consortium (2022). Comparison of outcomes of different biopsy schedules among men on active surveillance for prostate cancer: An analysis of the G.A.P.3 global consortium database. The Prostate, 82 (7), 876–879. https://doi.org/10.1002/pros.24330
Remmers, S., Helleman, J., Nieboer, D., Trock, B., Hyndman, M. E., Moore, C. M., Gnanapragasam, V., Shiong Lee, L., Elhage, O., Klotz, L., Carroll, P., Pickles, T., Bjartell, A., Robert, G., Frydenberg, M., Sugimoto, M., Ehdaie, B., Morgan, T. M., Rubio-Briones, J., Semjonow, A., … Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium (2022). Active Surveillance for Men Younger than 60 Years or with Intermediate-risk Localized Prostate Cancer. Descriptive Analyses of Clinical Practice in the Movember GAP3 Initiative. European urology open science, 126–133. https://doi.org/10.1016/j.euros.2022.05.012
Marenghi, C., Qiu, Z., Helleman, J., Nieboer, D., Rubio-Briones, J., Carroll, P. R., Lee, L. S., Valdagni, R., Boutros, P. C., Nicolai, N., & Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium (2022). Adverse Pathological Findings at Radical Prostatectomy following Active Surveillance: Results from the Movember GAP3 Cohort. Cancers, 14(15), 3558. https://doi.org/10.3390/cancers14153558
Doan, P., Scheltema, M. J., Amin, A., Shnier, R., Geboers, B., Gondoputro, W., Moses, D., van Leeuwen, P. J., Haynes, A. M., Matthews, J., Brenner, P., O'Neill, G., Yuen, C., Delprado, W., Stricker, P., & Thompson, J. (2022). Final Analysis of the Magnetic Resonance Imaging in Active Surveillance Trial. The Journal of urology, 208(5), 1028–1036. https://doi.org/10.1097/JU.0000000000002885
Gondoputro, W., Doan, P., Katelaris, A., Scheltema, M. J., Geboers, B., Agrawal, S., Liu, Z., Yaxley, J., Savdie, R., Rasiah, K., Frydenberg, M., Roberts, M. ,., Malouf, D., Wong, D., Shnier, R., Delprado, W., Emmett, L., Stricker, P. D., & Thompson, J. (2023). 68Ga-PSMA-PET/CT in addition to mpMRI in men undergoing biopsy during active surveillance for low- to intermediate-risk prostate cancer: study protocol for a prospective cross-sectional study. Translational andrology and urology, 12 (10), 1598–1606. https://doi.org/10.21037/tau-22-708